Scientist II, Developability

Responsibilities

• Lead developability R&D projects: design, optimize, and execute high throughput developability assays to expand BigHat’s toolkit.
• Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.
• Support late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates.
• Serve as the Developability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones.
• Work cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure.
• Proactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization.

Key Responsibilities

Skills Knowledge and Expertise

• PhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.
• Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization.
• Track record of translating complex data into clear results and recommended actions.
• Experience with protein structures and antibody engineering.
• Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.
• Nice-to-haves include prior experience working in a dynamic start-up environment, working as a project lead, and working with automation.

Total Rewards

The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

What BigHat Offers

Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)

Dental, and vision coverage through Guardian

Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more

401(k) with company match

• DTO, two weeks of company-wide shutdown, and 12 company holidays
• Paid parental leave