Scientist III - LC/MS (Bioanalytical)

Responsibilities

• Lead assay development, validation, and sample analysis of biologics, proteins, peptides, ADCs, and/or biomarkers using chromatographic and mass spectrometric (LC/MS) techniques in support of preclinical, clinical, and product release studies.
• Plan and direct experimental design for junior staff
• Drive bioanalytical projects to align with client timelines
• Frequent communication with clients to discuss technical details and provide project updates.
• Advise clients on LC/MS assay best practices
• Author documents (methods, SOPs, reports)
• Statistical analysis of bioanalytical data
• Review of documentation
• Peer review raw data
• Prepare reagents
• Troubleshoot assays
• Design assay runs independently
• Responsible for prompt identification and notification of deviations
• Write plans/reports for sample analysis
• Order and keep accurate inventories of supplies for laboratory needs and forecast future needs based on projected project needs
• Perform assays according to GLP guidance or SOPs

Minimum Preferred Qualifications: Skills

Experience with development, validation and execution of chromatographic and mass spectrometric assays (LC/MS), and/or ability to perform most tasks associated with custom research planning and bench work

Must work effectively within team to meet objectives under time constraints

Ability to take direction well and multi-task

Detail oriented and highly organized

Demonstrated expertise in chromatographic assay development

Advanced capabilities in data analysis, data visualization statistical analysis

LC/MS assay development and validation

• Microsoft word, Excel, Sciex OS/Analyst, MassLynx, Chromeleon, Watson LIMS, JMP, Graphpad Prism
• Ability to develop protein binding, CYP inhibition, CYP induction, or CYP phenotyping and/or ability to develop chromatographic assays using HPLC or LC/MS/MS.
• Experience working in a GxP environment preferred
• Excellent oral and written communication skills

Minimum Preferred Qualifications: Education/Experience

Bachelor’s degree in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than 12 years’ experience in a scientific laboratory environment; or

Master’s degree in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than ten (10) years’ experience in a scientific laboratory environment; or

PhD in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than eight (8) years’ experience in a scientific laboratory environment

Demonstrated expertise in developing chromatographic and mass spectrometric assays including LC/MS and LC/MS/MS for bioanalytical studies by extracting analytes of interest from complex biological matrices using protein precipitation, liquid-liquid, solid phase, immunoprecipitation or other extraction technique

Advanced capabilities in data analysis, data visualization statistical analysis

Supervisory Responsibility

This position may supervise Analyst I/II/III

Supervision Received

Infrequent supervision and instructions

Frequently exercises discretionary authority

Working Environment

Primarily laboratory environment

• Exposure to biological fluids with potential exposure to infectious organisms
• Rare exposure to skin and lung irritants, toxic materials, and hazardous waste
• Personal protective equipment required, such as protective eyewear, garments, and gloves
• Routinely uses standard office equipment such as computers, phones, photocopiers, and filing cabinets

Physical Demands

• Ability to work in an upright and/or stationary position for up to 8 hours per day
• Repetitive hand movement of both hands with the ability to make fast, simple, repeated movements of the fingers, hands, and wrists to operate lab equipment

Frequent mobility needed

• Frequent crouching, stooping, with frequent bending and twisting of upper body and neck
• Light to moderate lifting and carrying (or otherwise moves) objects including laboratory equipment, laboratory supplies, and laptop computer with a maximum lift of 20 pounds
• Ability to access and use a variety of computer software
• Ability to communicate information and ideas so others will understand, with the ability to listen to and understand information and ideas presented through spoken words and sentences
• Frequently interacts with others to obtain or relate information to diverse groups

Requires multiple periods of intense concentration

• Performs a wide range of variable tasks as dictated by variable demands and changing conditions with little predictability as to the occurrence
• Ability to perform under stress and multi-task
• Regular and consistent attendance
• Position Type and Expected Hours of Work

This is a full-time position

• Some flexibility in hours is allowed, but the employee must be available during the “core” work hours as published in the BioAgilytix Employee Handbook
• Occasional weekend, holiday, and evening work required

BENEFITS AND OTHER PERKS

Medical Insurance (HDHP with HSA; PPO), Dental Insurance, Vision Insurance, Flexible Spending Account (medical; dependent care), Short Term Disability | Long Term Disability Life Insurance, Paid Time Off (4 weeks per year), Parental Leave, Paid Holidays (9 scheduled; 5 floating), 401k with Employer Match, Employee Referral Program

COMMITMENT TO EQUAL OPPORTUNITY

BioAgilytix provides equal employment opportunities to all employees and applicants for employment without regard to race, color, ancestry, national origin, gender, sexual orientation, marital status, religion, age, disability, gender identity, results of genetic testing, service in the military, or any other group protected by federal, state, or local law.

To learn more about how we collect, use, and protect your information, please review our Privacy Policy and Terms of Use.