Principal Software Engineer

Responsibilities

• As a

core services and user experiences

• of a next-generation clinical data and analytics platform—while influencing architecture, engineering standards, and technical direction.
• bringing modern capabilities—including AI-assisted and agentic workflows—into production-grade systems
• Design, develop, test, and deploy
• scalable, secure, and highly interactive web applications

Own and evolve

• core platform modules, from concept through release and support
• Influence application and system architecture with a focus on
• performance, reliability, security, and maintainability

Lead by example through

• clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
• Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
• Provide technical mentorship and guidance to other engineers on the team
• Diagnoses and resolves complex production issues across distributed systems
• Ensure solutions meet
• eClinical Solutions quality standards
• and applicable industry regulations
• Contribute to technical documentation including design specs, acceptance criteria, and release notes
• AI & Modern Engineering Focus

Requirements

• Bachelor’s or Master’s degree in Computer Science or equivalent practical experience
• 10+ years in software design and development using the Microsoft technology stack preferred
• Expert-level proficiency in
• C#, .NET, and ASP.NET (MVC/Web APIs)
• Strong experience building
• full-stack web applications
• (Angular, TypeScript, HTML, CSS)
• Solid understanding of
• software design principles, patterns, and best practices

Preferred

• Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
• Experience with clinical trial data, life sciences, or regulated SaaS environments

, you will be a

• technical leader within the elluminate Product Development team. You’ll help design and build the
• This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and

Your day to day

We’re actively incorporating

AI-powered capabilities

into our platform, and you’ll help shape how this is done responsibly and effectively in an enterprise environment. This includes:

Integrating

• LLMs and AI services into .NET- and Python-based systems
• Designing and implementing
• AI-assisted workflows, copilots, or intelligent automation features

Working with agentic AI patterns

• (e.g., task orchestration, tool-using agents, workflow automation)
• Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
• Collaborating with data and platform teams to operationalize AI—not just prototype it

Deep ML expertise is not required

—we’re looking for strong engineers who understand how to

apply AI capabilities in real products

Take the first step toward your dream career. Here is what we are looking for in this role.

Experience across the full

Software Development Lifecycle

• (Agile preferred)
• Proven ability to work independently while collaborating effectively in a fast-paced environment
• Excellent communication, documentation, and technical leadership skills

AI & Platform Experience

Hands-on experience integrating

LLM-based services

• (e.g., OpenAI, Azure OpenAI, or similar) into applications
• Experience using

Python and/or .NET alongside AI/LLM workflows

• Familiarity with agent-based or workflow-driven AI architectures is a strong plus
• Understanding of secure and responsible AI usage in enterprise systems

Experience with

• microservices, distributed systems, and cloud platforms (AWS preferred)
• Secure development experience, including awareness of common vulnerabilities and mitigations
• Experience building data visualizations or analytics-driven user experiences

AI Use Statement

Employees are expected to appropriately leverage company-approved AI tools to improve productivity and quality while adhering to company policies, protecting confidential information, validating AI-generated content, and exercising sound professional judgment. AI is intended to augment—not replace—professional judgment, critical thinking, accountability, and decision-making. Accountability for all work remains with the employee.

Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours!

eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here:

https://topworkplaces.com/company/eclinical-solutions/ eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!

We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need.

#LI-AB1

US Pay Ranges

• $152,000
• $190,000 USD